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. 2021 Apr 26;10(4):28. doi: 10.1167/tvst.10.4.28

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Figure 3. — Consecutive corneal photographs taken by the Smart Eye Camera invented for the evaluation of dry eye disease (DED). The photographs have been obtained for a DED case with positive objective signs and a short tear film breakup time (TFBUT). (A) Just after opening the eye, the fluorescence enhanced tear spread into the whole cornea. (B) One second after opening the eye, the superior extension of the tear film can be observed (Gibbs–Marangoni effect). (C) Two seconds after opening the eye, tear film breakup was still not observed. (D) Three seconds after opening the eye, a dry spot of the tear film was observed in the left part of the cornea. (E) Four seconds after opening the eye, the dry spot was clearly observed in several parts of the cornea. (F) Five seconds after opening the eye, the area of the dry spot expanded, suggesting a line break in the breakup pattern.