Table 2.
Core marker genes for the current PAD/VCD MM dataset (full cohort/VCD cohort).
| Gene ID1 | Cohort | Regulation in responders/non-responders2 | Molecular function3 |
|---|---|---|---|
| ARPC2 | Full, VCD | Up/down | control of actin polymerization |
| CDHR4 | VCD | Down/up | cell adhesion protein; sorting of heterogeneous cell types |
| EFCAB8 | VCD | Down/up | Calcium ion binding |
| EIF4BP8 | Full, VCD | Down/up | eukaryotic translation initiation factor 4B pseudogene 8 |
| KLHDC7B | Full | Down/up | Kelch domain-containing protein 7B |
| OSR2 | Full, VCD | Down/up | transcription factor |
| RPL21P1 | Full | Down/up | ribosomal protein L21 pseudogene 1 |
| SETP4 | Full, VCD | Down/up | SET pseudogene 4 |
| SLC25A6P3 | VCD | Down/up | mitochondrial carrier; adenine nucleotide translocator, member 6 pseudogene 3 |
| TOGARAM1 | VCD | Down/up | microtubule binding |
| TRIM9 | Full, VCD | Down/up | includes TRIM motif with three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region |
| TSSC4 | Full, VCD | Down/up | tumor suppressing subtransferable candidate 4 |