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. Author manuscript; available in PMC: 2022 Apr 12.
Published in final edited form as: Angew Chem Int Ed Engl. 2021 Mar 10;60(16):8867–8873. doi: 10.1002/anie.202014096

Figure 1.

Figure 1.

(a) Analysis of reagents and their logP values for utility in protein transmembrane footprinting. LogP values were simulated using the web-based interactive software from Molinspiration Cheminformatics. (b) Enhanced partition of PFIPI into a micelle with tip sonication showing improved yields of transmembrane footprinting (blue +). The region in magenta is the water-accessible extramembrane domain, whereas the region in cyan is hydrophobic transmembrane. The blue dashed line is the boundary dividing the two domains