Table 1.
Clinical characteristics of the 5 subjects studied
| Subjects |
||||||
|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | Means ± SD | |
| Anthropometrics | ||||||
| Age (years) | 43 | 31 | 31 | 65 | 72 | 48.4 ± 19.2 |
| Sex | F | M | M | M | M | |
| Body mass index (kg/m2) | 20.8 | 30.8 | 29 | 23 | 25 | 26.2 ± 4.6 |
| Respiratory mechanics | ||||||
| Tidal volume (mL) | 400 | 300 | 300 | 460 | 440 | 380.0 ± 76.6 |
| Respiratory rate (bpm) | 26 | 30 | 29 | 24 | 24 | 26.6 ± 2.8 |
| Peak pressure (cmH2O) | 30 | 28 | 28 | 20 | 30 | 27.2 ± 4.15 |
| Plateau pressure (cmH2O) | 26 | 26 | 25 | 18 | 28 | 24.6 ± 3.85 |
| PEEP (cmH2O) | 14 | 12 | 10 | 8 | 5 | 9.8 ± 3.4 |
| Driving pressure (cmH2O) | 12 | 14 | 15 | 10 | 23 | 14.8 ± 5.0 |
| Respiratory system compliance (mL/cmH2O) | 33.3 | 21.4 | 20.0 | 46.0 | 19.1 | 28.0 ± 11.6 |
| Gas exchange | ||||||
| PaO2 (mmHg) | 105.0 | 62.0 | 65.3 | 64.0 | 62.5 | 71.8 ± 18.8 |
| FiO2 | 0.90 | 0.85 | 0.80 | 0.80 | 0.60 | 0.79 ± 0.11 |
| PaO2/FiO2 (mmHg) | 117 | 72.9 | 81.6 | 80.0 | 104.2 | 91.1 ± 18.6 |
| AaDO2 (mmHg) | 452.9 | 451.1 | 423.6 | 457.0 | 267.3 | 410.3 ± 81.0 |
| SaO2 | 98.0 | 89.1 | 91.6 | 92.7 | 88.7 | 92.0 ± 3.8 |
| pH | 7.39 | 7.31 | 7.36 | 7.43 | 7.29 | 7.36 ± 0.06 |
| PaCO2 (mmHg) | 71.0 | 79.0 | 69.5 | 42.0 | 83.3 | 69.0 ± 16.1 |
| EtCO2 (mmHg) | 53 | 61 | 66 | 29 | 63 | 54.4 ± 15.0 |
| Base excess (mEq/L) | 15.2 | 10.4 | 10.7 | 3.2 | 9.7 | 9.8 ± 4.3 |
| PvO2 (mmHg) | 36.4 | 39.7 | 41.1 | 34.2 | 41.3 | 38.6 ± 3.1 |
| SvO2 | 69.0 | 69.0 | 74.1 | 68.0 | 70.0 | 70.0 ± 2.3 |
| PvCO2 (mmHg) | 80.1 | 85.7 | 76.6 | 45.7 | 90.8 | 75.9 ± 17.7 |
| QVA/QT | 0.29 | 0.50 | 0.47 | 0.43 | 0.46 | 0.43 ± 0.08 |
| Hemodynamics | ||||||
| Temperature (°C) | 36.8 | 37.0 | 38.1 | 36.0 | 36.0 | 36.8 ± 0.87 |
| Cardiac output (L/min) | 8.06 | 9.49 | 10.40 | 9.45 | 10.55 | 9.58 ± 0.99 |
| VO2 (mL/min) | 326 | 271 | 306 | 288 | 319 | 302.0 ± 22.7 |
| VCO2 (mL/min) | 277 | 230 | 260 | 244 | 272 | 256.7 ± 19.3 |
| Laboratory | ||||||
| Hemoglobin (g/dL) | 9.5 | 10.0 | 11.7 | 8.6 | 11.4 | 10.2 ± 1.3 |
| White blood count (109/L) | 18.4 | 5.0 | 30.6 | 15.8 | 15.6 | 17.1 ± 9.1 |
| ALT (U/L) | 34 | 198 | 342 | 15 | 60 | 129.8 ± 138.7 |
| AST (U/L) | 74 | 81 | 86 | 15 | 21 | 55.4 ± 34.5 |
| Bilirubin (mg/dL) | 0.5 | 1.1 | 1.1 | 0.4 | 0.5 | 0.72 ± 0.35 |
| Platelets (109/L) | 365 | 49 | 79 | 188 | 261 | 188.4 ± 140.2 |
| Fibrinogen (g/dL) | 68 | 134 | 365 | 525 | 273.0 ± 210.1 | |
| D-dimer (ng/mL) | 1060 | 900 | 3339 | 918 | 1554 ± 1191 | |
| Procalcitonin (µg/L) | 0.54 | 0.21 | 0.11 | 0.19 | 0.12 | 0.24 ± 0.17 |
| CT scan variables | ||||||
| Lung weight (g) | 2064 | 1496 | 937 | 1914 | 1401 | 1563 ± 447 |
| Gas volume (mL) | 1637 | 525 | 482 | 3007 | 1215 | 1373 ± 1034 |
| Non-aerated tissue fraction | 0.40 | 0.39 | 0.36 | 0.27 | 0.26 | 0.33 ± 0.06 |
AaDO2, alveolar-arterial PO2 difference; PEEP, positive end-expiratory pressure; PaO2, arterial partial pressure of O2; PaCO2, arterial partial pressure of CO2; FiO2, inspired O2 fraction; EtCO2, end-tidal CO2; PvO2, mixed venous O2 content; PvCO2,mixed venous CO2 content; SaO2, arterial oxygen saturation; SvO2, mixed venous oxygen saturation; VO2, oxygen consumption, VCO2, CO2 production.