Table 6.
Prognostic scores including histopathological factors reported in the literature
| Author, year pub |
Type of patients included | Predicted end point | Variables included |
|---|---|---|---|
| Becker Germany 2012 Ann Surg |
NAa + Sb | OSc | yT yN Histopathological tumor regression |
| Bria32 Italy 2012 Ann Oncol |
S | CSSd | Sex Stage Margins Tumor location Lymph node involvement APC IHCe expression Fhit IHC expression |
| OS | Age Sex Stage Margins Tumor location Lymph node involvement APC IHC expression HER2 expression |
||
| Kologlu25 Turkey 2000 Am J Surg |
S | OS and DFSf | pT pN (AJCCg 1992, UICCh 1997) pM Metastatic lymph node ratio Resectability Tumor location Lymph node dissection (D1 or D2) Borrman classification Lauren classification |
| Vieira Costa22 Brazil 2006 Ann Surg Oncol |
S | OS | Sex Weight loss Pre-operative lymphocyte count Lymph node ratio Lymph node dissection TNM stage |
| Zhu29 China 2014 BMJ Cancer |
S | OS | Histological grading stage |
| Marrelli27 Italy 2005 Ann Surg |
S | DFS | pN pT Lymph node dissection (D1 vs D2-3) Tumor location Age |
| Sekiguchi28 Japan 2016 J Gastroenterol |
S Early tumors |
Lymph node metastasis | Tumor size Tumor depth Histologic type Ulcerative features Lymphovascular invasion |
| Haraguchi26 Japan 2018 Oncotarget |
S | OS Tumor progression |
Tumor depth and size |
| Qian13 China 2016 Drug Des Devel Ther |
S + Ai | OS Treatment response |
Lymph node rate Lymphovascular invasionpTNM (I-IV) Preoperative CEA level Preoperative hemoglobin |
| Park42 Korea 2015 Gastric cancer |
S in early GC j (stage I) | DFS | Age Sex pTNM (stage) Lymphovascular invasion Perineural invasion CEA level |
| Marubini43 Italy 1993 Eur J Cancer |
S±A | OS | Age Tumor depth Tumor location Lymph node involvement |
| Ichikura41 Japan 1993 Surg Today |
S±A with serosal invasion | DFS | Lymph node involvement Macroscopic typeSerosal invasion (macroscopic) Interstitial conective tissue |
| S±A without serosal invasion | DFS | Lymph node involvement Serosal invasion (macroscopic) Venous invasion |
|
| Kattan44 US 2003 J Clin Oncol |
S | Nomogram for CSS | Age Sex Tumor location Laurén classification Number of positive lymph nodes Number of negative lymph nodes Tumor depth |
| Dikken34 US / Holland 2013 Ann Surg Oncol |
S±A | Nomogram for conditional probability of survival | Sex Age Tumor location Laurén classification Tumor diameter Positive lymph nodes Negative lymph nodes Tumor depth |
| Han35 Korea 2012 J Clin Oncol |
S±A | Nomogram for OS | Sex Age Tumor location Tumor depth Number of metastatic lymph nodes Number of negative lymph nodes |
aNA: Neoadjuvanttherapy. bS: Surgery. cOS: Overall survival. dCSS: Cancer-specific survival. eIHC: Immunohistochemistry. fDFS: Disease-free survival. gAJCC: American Joint Committee on Cancer. hUICC: Union for International Cancer Control. iA: Adjuvant therapy. wjGC: Gastric cancer