Figure 5.

Cox proportional hazards model for viral RNA clearance. An aHR <1 denotes longer time to SARS-CoV-2 viral RNA clearance in the upper respiratory tract as measured by RT-PCR. To account for missing data points, 20 data sets were imputed using PPM MICE. Model selection using LASSO was performed on each of the 20 data sets. The top 9 variables of 35—selected 15 or more times out of 20 (Supplementary Table 2)—were chosen for inclusion in the Cox proportional hazards model, which was performed using the pooled imputed data set. ^aStandardized log mean fluorescence intensity and treated as a time-varying variable. Abbreviations: aHR, adjusted hazard ratio; ECD, spike ectodomain; hCoV, human coronavirus; LASSO, least absolute shrinkage and selection operator; MICE, multiple imputation by chained equation; PPM, predictive mean matching; RT-PCR, reverse transcription polymerase chain reaction; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; S-RBD, spike receptor binding domain.