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. 2021 Apr 15;144(9):2696–2708. doi: 10.1093/brain/awab148

Figure 3.

Figure 3

Inflammatory pathology in COVID-19 brains. (A) Section of the hypoglossal nucleus shows several motor neurons and a microglial module (arrow). (B) An adjacent section stained for CD68, showing clustered microglia in the nodule. Inset: Microglia in close apposition to a hypoglossal neuron (CD68). (C) An adjacent section stained for CD3, showing scattered T cells in the tissue and associated with the microglial nodule. (D) An adjacent section stained for CD8 showing that many of the T cells are CD8+. (E) The locus coeruleus contains a microglial nodule with a degenerating neuron in the centre, identified by its residual neuromelanin (arrow). (F and G) Neurons of the dorsal motor nucleus of the vagus surrounded by CD68+ microglia. (H and I) Microglial nodules in the dentate nucleus (arrows in H), neuron in the middle of a nodule (arrow in I), CD68. Scale bar in D = 200 µm for A–D; in E = 10 µm; F and G = 50 µm; H = 100 µm; I = 50 µm; J = 1 mm; and K = 250 µm.