Table 3.

Performance of RF model for family specific prediction of PPI modulators

PPI family model	Testing	Positives	Negatives	Sens	Spec	FPR	Prec	F1-Score	MCC	ROC AUC	PRC AUC
Bromodomain_Histone	10-Fold CV	211	211	0.91	0.87	0.13	0.91	0.89	0.77	0.95	0.94
	Testset	70	70	0.91	0.81	0.19	0.91	0.87	0.73	0.94	0.93
BCL2-Like_BAX/BAK	10-Fold CV	60	60	0.83	0.92	0.08	0.83	0.87	0.75	0.96	0.97
	Testset	20	20	0.8	0.9	0.1	0.8	0.84	0.7	0.92	0.94
LEDGF_IN	10-Fold CV	58	58	0.93	0.84	0.16	0.93	0.89	0.78	0.96	0.97
	Testset	20	20	0.85	0.85	0.15	0.85	0.85	0.7	0.97	0.97
LFA_ICAM	10-Fold CV	35	35	0.94	0.94	0.06	0.94	0.94	0.89	0.99	0.99
	Testset	12	12	0.92	1	0	0.92	0.96	0.92	0.99	0.99
MDM2-Like_P53	10-Fold CV	73	73	0.88	0.93	0.07	0.88	0.9	0.81	0.97	0.97
	Testset	24	24	0.88	0.92	0.08	0.88	0.89	0.79	0.93	0.96
RAS_SOS1	10-Fold CV	30	30	0.83	0.87	0.13	0.83	0.85	0.7	0.93	0.95
	Testset	10	10	0.6	0.9	0.1	0.6	0.71	0.52	0.82	0.83
XIAP_Smac	10-Fold CV	58	58	0.98	0.95	0.05	0.98	0.97	0.93	0.98	0.97
	Testset	19	19	0.95	0.95	0.05	0.95	0.95	0.89	0.97	0.96
RBD_hACE2	10-Fold CV	21	21	0.86	0.95	0.05	0.86	0.9	0.81	0.93	0.96
WDR5_MLL1	10-Fold CV	18	18	0.83	0.89	0.11	0.83	0.86	0.72	0.94	0.95
KEAP1_NRF2	10-Fold CV	18	18	0.78	0.89	0.11	0.78	0.82	0.67	0.93	0.94
CD4_gp120	10-Fold CV	26	26	0.96	0.96	0.04	0.96	0.96	0.92	0.99	0.99