Table 2.
KEGG pathway enrichment results of four modules (top ten)
| Modules | ID | Description | Adjusted P-value | Related genes | Count |
|---|---|---|---|---|---|
| Turquoise | hsa05034 | Alcoholism | 4.28E-10 | HIST1H2AE;HIST1H3H;HIST1H4I;GNG11;HIST1H2AG;HIST1H2AI;HIST2H2BE HIST1H2BD;HIST1H4K;HIST1H2BJ;SLC18A2;HIST1H4H;HIST1H2AC;HIST2H4A; HIST1H2BG;HIST1H2BL;HIST1H2BK;HIST1H2BH;HIST1H2BC;HIST1H2BO; MAOB |
21 |
| hsa05322 | Systemic lupus erythematosus | 5.59E-10 | MYLK;GP9;GUCY1B1;ITGA2;COL1A2;PTGS1;ARHGEF12;PRKG1;VWF;GP1BA; ITGA2B;ITGB3;PLCB4;F2RL3;GP6 |
18 | |
| hsa04611 | Platelet activation | 5.66E-08 | MYLK;GP9;GUCY1B1;ITGA2;COL1A2;PTGS1;ARHGEF12;PRKG1;VWF;GP1BA; ITGA2B;ITGB3;PLCB4;F2RL3;GP6 |
15 | |
| hsa04512 | ECM-receptor interaction | 0.000108 | ITGB5;GP9;ITGA2;COL1A2;VWF;GP1BA;ITGA2B;ITGB3;GP6 | 9 | |
| hsa04540 | Gap junction | 0.000108 | EGF;GUCY1B1;PDGFA;LPAR1;PRKG1;TJP1;PLCB4;TUBB1;TUBA8 | 9 | |
| hsa05203 | Viral carcinogenesis | 0.000123 | H4C14;H2BC21;H2BC4;H2BC5;H2BC8;H2BC9;H4C8;H2BC11;H4C9;H2BC12; H2BC13;H4C12;H2BC17;CDKN2A |
14 | |
| hsa04022 | cGMP-PKG signaling pathway | 0.000247 | OPRD1;MYLK;PDE5A;GUCY1B1;PDE2A;TRPC6;PRKG1;ADRA2A;PDE3A; SLC8A3;PLCB4;MYL9 |
12 | |
| hsa04510 | Focal adhesion | 0.000385 | MYLK;ITGB5;EGF;VEGFC;ITGA2;PDGFA;COL1A2;CAV2;VWF;BCAR1; ITGA2B;ITGB3;MYL9 |
13 | |
| hsa04270 | Vascular smooth muscle contraction | 0.002487 | PLA2G2C;MYLK;GUCY1B1;CALD1;ARHGEF12;PRKG1;PLCB4;MYL9;PPP1R14A | 9 | |
| hsa04810 | Regulation of actin cytoskeleton | 0.002582 | IQGAP3;MYLK;ITGB5;EGF;ITGA2;PDGFA;LPAR1;ARHGEF12;BCAR1;ITGA2B; ITGB3;MYL9 |
12 | |
| Blue | hsa04110 | Cell cycle | 3.14E-24 | CDC20;CDKN2C;ORC1;BUB1;MCM6;CDC25A;MCM2;MAD2L1;CCNA2;CCNB1; CDC25C;PTTG1;TTK;MCM4;CCNE2;CHEK1;CDK1;ESPL1;BUB1B;CCNB2;PKMYT1; PLK1;ORC6;CDC6;CCNE1;CDC45 |
26 |
| hsa04114 | Oocyte meiosis | 1.11E-13 | CDC20;SPDYA;BUB1;SGO1;MAD2L1;CCNB1;CDC25C;PTTG1;FBXO5;CCNE2; FBXO43;CDK1;ESPL1;CCNB2;PKMYT1;PLK1;AURKA;CCNE1 |
18 | |
| hsa04914 | Progesterone-mediated oocyte maturation | 1.05E-08 | SPDYA;BUB1;CDC25A;MAD2L1;CCNA2;CCNB1;CDC25C;CDK1;CCNB2; PKMYT1;PLK1;AURKA |
12 | |
| hsa05322 | Systemic lupus erythematosus | 2.54E-06 | H3C2;H2AC4;H3C3;H4C4;H4C6;H3C7;H3C8;H2AC12;H2AC14;H4C11;H3C11 | 11 | |
| hsa04115 | p53 signaling pathway | 6.76E-06 | RRM2;CCNB1;CCNE2;CHEK1;CDK1;CCNB2;CCNE1;GTSE1 | 8 | |
| hsa05034 | Alcoholism | 9.77E-06 | GNG4;H3C2;H2AC4;H3C3;H4C4;H4C6;H3C7;H3C8;H2AC12;H2AC14;H4C11;H3C11 | 12 | |
| hsa05166 | Human T-cell leukemia virus 1 infection | 4.74E-05 | CDC20;CDKN2C;MAD2L1;CCNA2;TERT;PTTG1;CCNE2;CHEK1;ESPL1; BUB1B;CCNB2;CCNE1 |
12 | |
| hsa04218 | Cellular senescence | 5.66E-05 | CDC25A;CCNA2;CCNB1;CCNE2;CHEK1;CDK1;FOXM1;CCNB2;MYBL2;CCNE1 | 10 | |
| hsa03460 | Fanconi anemia pathway | 9.35E-05 | UBE2T;RAD51;FANCI;RMI2;BRCA1;EME1 | 6 | |
| hsa05203 | Viral carcinogenesis | 0.000115 | CDC20;CCR3;CCNA2;H4C4;H4C6;H4C11;SCIN;CCNE2;CHEK1;CDK1;CCNE1 | 11 | |
| Brown | hsa05322 | Systemic lupus erythematosus | 5.01E-06 | C1QA;C1QC;C1QB;FCGR1A;IL10;H2BC7;H2AC16;H3C12;H2AJ;ELANE;C3 | 11 |
| hsa05150 | Staphylococcus aureus infection | 0.000536 | C1QA;C1QC;C1QB;FCGR1A;IL10;CAMP;C3 | 7 | |
| hsa05142 | Chagas disease | 0.000772 | C1QA;C1QC;C1QB;FASLG;IL10;TGFBR1;C3 | 7 | |
| hsa05133 | Pertussis | 0.000889 | C1QA;C1QC;C1QB;IL10;IL23A;C3 | 6 | |
| hsa04610 | Complement and coagulation cascades | 0.001597 | C1QA;C1QC;C1QB;VSIG4;CLU;C3 | 6 | |
| hsa05168 | Herpes simplex virus 1 infection | 0.002736 | FASLG;PILRB;ZNF10;ZNF597;C3;ZNF563;ZNF540;ZNF571;ZNF607;ZNF284; ZNF600;ZNF543;ZNF304;ZNF547;ZNF419;ZNF132 |
16 | |
| hsa05165 | Human papillomavirus infection | 0.003638 | FZD5;FN1;WNT7A;SPP1;ITGA1;CREB3L1;WNT11;ITGA7;CCNA1;THBS1;NOTCH3 | 12 | |
| hsa05030 | Cocaine addiction | 0.005867 | MAOA;SLC18A1;CREB3L1;GRIN3B; | 4 | |
| hsa05034 | Alcoholism | 0.006577 | H2BC7;H2AC16;H3C12;MAOA;SLC18A1;CREB3L1;H2AJ;GRIN3B | 8 | |
| hsa04512 | ECM-receptor interaction | 0.009794 | FN1;SPP1;ITGA1;ITGA7;THBS1 | 5 | |
| Pink | hsa04657 | IL-17 signaling pathway | 2.17E-05 | IL1B;CCL20;TNF;TNFAIP3;FOSB | 5 |
| hsa05323 | Rheumatoid arthritis | 0.000359 | IL1A;IL1B;CCL20;TNF | 4 | |
| hsa05332 | Graft-versus-host disease | 0.000482 | IL1A;IL1B;TNF | 3 | |
| hsa04940 | Type I diabetes mellitus | 0.000516 | IL1A;IL1B;TNF | 3 | |
| hsa04060 | Cytokine–cytokine receptor interaction | 0.000639 | IL1A;IL1B;CXCR4;CCL20;TNF;OSM | 6 | |
| hsa04668 | TNF signaling pathway | 0.000727 | IL1B;CCL20;TNF;TNFAIP3 | 4 | |
| hsa04380 | Osteoclast differentiation | 0.001199 | IL1A;IL1B;TNF;FOSB | 4 | |
| hsa05162 | Measles | 0.001627 | IL1A;IL1B;TNFAIP3;CD209 | 4 | |
| hsa05418 | Fluid shear stress and atherosclerosis | 0.001627 | IL1A;IL1B;NFE2L2;TNF | 4 | |
| hsa05321 | Inflammatory bowel disease | 0.00173 | IL1A;IL1B;TNF | 3 |