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. 2021 Mar 27;8(8):nwab053. doi: 10.1093/nsr/nwab053

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© The Author(s) 2021. Published by Oxford University Press on behalf of China Science Publishing & Media Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Immunogenic evaluation of candidate antigen formulations mixed with alum or AS01B adjuvant in rabbits. (A and B) Rabbits were immunized intramuscularly with various doses of individual (RBD or NTD) or combined (RBD + NTD) immunogens mixed with alum or AS01B adjuvant or adjuvant only (sham) (n = 4). Neutralizing antibody titer against live SARS-CoV-2 was measured. Data points represent mean ± SEM of individual rabbits from four independent experiments; error bars reflect SEM; horizontal lines indicate the geometric mean titer (GMT) of EC₅₀ for each group.