Figure 5.

Immunogenicity and protective efficacy of ReCovR+N in rhesus macaques. (A) Schematic diagram of ReCovR+N immunization and sample collection. (B) SARS-CoV-2-specific NAb titer was measured. Data points represent mean ± SD of individual macaques from four independent experiments. Error bars indicate SEM. Horizontal lines indicate the geometric mean titer of EC₅₀ for each group. Viral loads of (C) nasal and (D) throat swab specimens collected from the inoculated macaques at 2, 3, 5, 6 and 7 dpi were monitored. (Ε) Viral loads in various tissues from all the challenged macaques at 7 dpi were measured. RNA was extracted and viral load was determined by qRT-PCR. All data are presented as means ± SD from four independent experiments. Dotted lines indicate the limit of detection.