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MLOs induced by HIV-1 and SARS-CoV-2 to replicate. Left: HIV-1 infection prompts the formation of nuclear MLOs enriched with host factors, such as CPSF6 and SC35, and in viral components, such as vRNA, vDNA, capsid, and integrase. Right: SARS-CoV-2 N protein forms condensates in the cytoplasm to recruit exclusively intact vRNA genome against subgenomic vRNAs or host RNAs. Cartoon created with BioRender.com.
