Table 1.

Roles of MLOs in viral infection of pandemic viruses HIV-1 and SARS-CoV-2.

MLOs	Viruses: HIV-1 and SARS CoV-2	Roles of MLOs during infection	References
SGs	HIV-1	Regulation of genomic RNA and trafficking	Rao et al. (2018); Monette et al. (2020)
	SARS-CoV-2	Role of N protein in SARS-CoV-2 viral genome packing	Iserman et al. (2020); Perdikari et al. (2020); Savastano et al. (2020); Cubuk et al. (2021)
NPC	HIV-1	Nuclear import and integration site selection	Di Nunzio et al. (2013); Lelek et al. (2015); Marini et al. (2015); Buffone et al. (2018)
	SARS-CoV-2	Inhibition of IFN signaling	Miorin et al. (2020)
Nucleolus	HIV-1	Viral RNP assembly platform	Michienzi et al. (2000)
	SARS-CoV-2	Untranslated viral genomic RNA accumulation	Wu et al. (2020)
PML NBs	HIV-1	Silenced HIV-1 location	Lusic et al. (2013)
NSs	HIV-1	Potential sites of the PIC maturation	Scoca et al. (2020)
		Nuclear reverse transcription	Burdick et al. (2020);  Dharan et al. (2020); Rensen et al. (2020); Scoca et al. (2020); Selyutina et al. (2020)