Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Mar 28;170(2):299–306. doi: 10.1093/jb/mvab041

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021. Published by Oxford University Press on behalf of the Japanese Biochemical Society. All rights reserved

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)

PMC Copyright notice

Fig. 1. — Binding of the SARS-CoV-2 spike protein increases the rate of ACE2 activity. (A) Kinetic curves showing the effect of full-length SARS-CoV-2 spike on ACE2 activity. (B) Kinetic curves showing the effect of SARS-CoV-1 and SARS-CoV-2 RBD spike on ACE2 activity. (C) Michaelis–Menten plot showing effect of SARS-CoV-1 and SARS-CoV-2 RBD on catalytic activity of ACE2. k_obs, observed rate constant. (D) Catalytic rate (k_cat) and K_M of ACE2 in the absence or presence of SARS-CoV-1 and SARS-CoV-2 RBD spike protein [mean (95% confidence intervals)]. Pseudosubstrate concentration in (A) and (B) is 20 µM. Assays were conducted in two biological replicates.