TABLE 2.

Eight significantly enriched pathways related to lipid metabolism.

Pathway ID	Pathway term	Target gene list
ko04540	Gap junction	PDGFD, TUBA8, MAPK3, CSNK1D, CDK1, TUBAL3, PDGFRA, PLCB4, MAP3K2, HTR2C, GJD2, ADCY9, ENSOARG00000010782, PRKCG, PRKACA, DRD2
ko04152	AMPK signaling pathway	FOXO3, CPT1B, PRKAA2, CAB39L, STRADA, FBP2, ADRA1A, PFKL, PDPK1, RAB14, CDKL3, SCD, PPP2R5C, PRKAG2, CREB1, PIK3R1, HMGCR, PFKFB1, GYS1, HNF4A, EEF2, CAB39, ADIPOQ
ko00062	Fatty acid elongation	ACAA2, ENSOARG00000005352, HACD1, ACOT7, THEM5, ELOVL7, HADHA
ko01040	Biosynthesis of unsaturated fatty acids	ENSOARG00000005352, HACD1, ACOT7, ACOX1, SCD, ELOVL7, FADS1
ko00592	Alpha-Linolenic acid metabolism	ENSOARG00000009488, PLA2G4D, PLA2G2F, PLA2G2D, ACOX1, PLA2G3
ko00564	Glycerophospholipid metabolism	PLD2, ENSOARG00000009488, GPD1L, GPD1, PLA2G4D, ENSOARG00000003375, PTDSS1, PLA2G2F, GNPAT, PLA2G2D, GPCPD1, LPIN2, LPGAT1, LPCAT2, ENSOARG00000007826, PLA2G3
ko00591	Linoleic acid metabolism	ENSOARG00000009488, ENSOARG00000013497, PLA2G4D, PLA2G2F, PLA2G2D, CYP2E1, PLA2G3
ko00280	Valine, leucine, and isoleucine degradation	ALDH6A1, ENSOARG00000009300, ACAA2, MCCC2, AUH, ENSOARG00000018083, PCCA, BCKDHB, HMGCLL1, HADHA