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. 2021 Apr 15;9:648148. doi: 10.3389/fcell.2021.648148

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Copyright © 2021 Wang, Zhuo, Ma, Liu, Xu, He, Fu, Wang, Ji, Zhang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of MT1 KO on the expression of Nppc/Npr2 and genes related to progesterone synthesis. Nppc/Npr2 are genes regulating oocyte maturation and progesterone synthesis in mouse GV granulosa cells. (A) Nppc/Npr2 and Egfr. (B) Gene-related feedback. (C) Gene-related progesterone synthesis. (D) Gene-related cholesterol biosynthesis. Data represent the mean with SEM. (*P < 0.05, **P < 0.01) vs respective groups determined by one-way ANOVA followed by Tukey post hoc comparisons (n = 3).