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. 2021 Apr 15;9:642378. doi: 10.3389/fcell.2021.642378

FIGURE 4.

FIGURE 4

Current structural overview of SNX27. (A–C) The SNX27 PDZ domain (purple ribbons) bound to PDZ binding motifs (green cylinders). These motifs can take three different forms: unphosphorylated (PDB ID: 4Z8J) shown in panel (A); phosphorylated at the –3 position (PDB ID: 5EMB) shown in panel (B); and phosphorylated at the –5 position (PDB ID: 5EM9) shown in panel (C). Phosphorylation state is a further way to module binding through increased affinity. (D) SNX27 PX domain shown in gray ribbons (PDB ID: 4HAS). (E) The SNX27 FERM domain model was generated from the X-ray crystal structure of SNX17 FERM domain bound to the NPxY motif found in P-selectin (PDB ID: 4GXB); the F1, F2, and F3 sub-domains are labeled.