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Sorting nexin 27 (SNX27) binding to retromer and OTULIN. The SNX27 PDZ domain (light purple ribbons; PDB: 4Z8J) with a PDZbm (green cylinders) is shown with both VPS26 (dark blue ribbons; PDB ID: 4P2A) and OTULIN (yellow ribbons; PDB ID: 6SAK). Structural data suggest the interaction of SNX27 PDZ with retromer/cargo or OTULIN is mutually exclusive. OTULIN engages both the PDZbm site using a class I PDZbm and the β-hairpin required for interacting with VPS26.
