Table 1.
Baseline characteristics stratified by DISH and no DISH.
| Variables | DISH, n = 236 | No DISH, n = 1548 | p |
|---|---|---|---|
| Restrictive-like pulmonary function, n (%) | 90 (38.1) | 301 (19.4) | < 0.001 |
| Age, yrs, mean (SD) | 61.8 (8.8) | 55.9 (8.0) | < 0.001 |
| Sex, M/F | 164/72 | 731/817 | < 0.001 |
| Race, white/black, n | 168/68 | 939/609 | 0.001 |
| Pack-years smoking, mean (SD) | 41.0 (23.4) | 37.7 (20.6) | 0.023 |
| Current smoker, n (%) | 104 (44.1) | 950 (61.4) | < 0.001 |
| Weight, kg, mean (SD) | 98.5 (19.5) | 84.3 (18.8) | < 0.001 |
| Height, cm, mean (SD) | 173 (9) | 170 (10) | < 0.001 |
| BMI, kg/m2, mean (SD) | 33.0 (6.5) | 29.0 (6.0) | < 0.001 |
| Diabetes present | 62 (26.3%) | 164 (10.6%) | < 0.001 |
| Hypertension present | 132 (55.9%) | 577 (37.3%) | < 0.001 |
| High cholesterol | 118 (50%) | 516 (33.3%) | < 0.001 |
| Perc15 Insp (HU), mean (SD) | −902.1 (23.9) | −901.4 (24.2) | 0.664 |
| HAA, %, mean (SD) | 3.9 (1.6) | 3.8 (1.3) | 0.697 |
| E/I MLA, %, mean (SD) | 82.1 (4.7) | 81.6 (5.2) | 0.819 |
| Pi10, mm, mean (SD) | 3.6 (0.12) | 3.6 (0.12) | 0.218 |
| FEV1, % predicted, mean (SD) | 86.7 (16.0) | 92.3 (15.4) | < 0.001 |
| FVC, % predicted, mean (SD) | 84.7 (15.2) | 92.0 (15.0) | < 0.001 |
| FEV1/FVC ratio | 0.78 (0.05) | 0.78 (0.05) | 0.592 |
| TLC on CT, ltr | 5.5 (1.3) | 5.3 (1.3) | 0.027 |
| Kyphotic angle, mean (SD) | 39.2 (10.3) | 35.1 (10.6) | < 0.001 |
DISH: diffuse idiopathic skeletal hyperostosis; BMI: body mass index; Perc15: HU value at the 15th percentile (n = 1743); E/I MLA: expiratory to inspiratory ratio of mean lung attenuation (n = 1575); Pi10: square root of wall area of a 10-mm lumen perimeter (n = 1737); FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; HAA: high attenuation area; TLC: total lung capacity (n = 1743); CT: computed tomography; HU: Hounsfield units