Table 4.
Association between both DISH status and presence or absence of RSP pulmonary function on quality of life and function.
| Variables | No Dish, No RSP Pulmonary Function | DISH + No RSP Pulmonary Function | RSP Pulmonary Function + No DISH | Both DISH and RSP Pulmonary Function |
|---|---|---|---|---|
| No. subjects | 1247 | 146 | 301 | 90 |
| FEV1, % predicted, mean (SD) | 97.1 (12.4) | 94.9 (12.7) | 72.2 (9.7)* | 73.3 (10.8)* |
| FVC, % predicted, mean (SD) | 97.1 (11.4) | 93.2 (11.7)* | 71.1 (7.8)*^ | 70.8 (8.5)*^ |
| mMRC Dyspnea Scale, mean (SD) | 0.8 (1.2) | 0.8 (1.1) | 1.5 (1.5)*^ | 1.3 (1.5)*^ |
| SGRQ Total, mean (SD) | 17.8 (19.0) | 16.8 (17.4) | 31.6 (23.7)*^ | 26.2 (22.8)*^† |
| SF-36 PCS, mean (SD) | 48.0 (9.8) | 47.8 (9.4) | 42.1 (10.5)*^ | 42.6 (11.0)* |
| SF-36 MCS, mean (SD) | 49.1 (11.3) | 50.6 (11.3) | 46.5 (12.5)*^ | 50.5 (10.4)† |
| BODE score, mean (SD) | 0.52 (0.93) | 0.43 (0.84) | 1.3 (1.4)*^ | 1.0 (1.4)*^ |
| 6-min walk distance (feet), mean (SD) | 1560 (323)^ | 1480 (351) | 1326 (347)*^ | 1314 (390)*^ |
p < 0.0001 for comparison to No DISH/No PRISm pulmonary function group.
p < 0.001 for comparison to DISH/no PRISm pulmonary function.
p < 0.05 for comparison to PRISm pulmonary function/no DISH.
Subjects grouped by both DISH status and presence or absence of RSP pulmonary function to assess the effect of DISH and or RSP on quality of life and function. Comparisons were made across groups using ANOVA, with t tests between groups to define significant differences.
DISH: diffuse idiopathic skeletal hyperostosis; RSP: restrictive spirometric pattern; FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; SF-36: Medical Outcomes Study Short-form 36 questionnaire (n = 1423); BODE index: Body mass index, airflow Obstruction, Dyspnea and Exercise capacity (n = 1774); SGRQ: St. George’s Respiratory Questionnaire (n = 1783); mMRC: modified Medical Research Council; PCS: physical component score; MCS: mental component score.