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. 2021 Jan 7;12(4):448–471. doi: 10.1039/d0md00370k

Fig. 28. Replacement of the 1,2-disubstituted pyrrolidine core of a series of PI3Kγ/δ dual inhibitors with an azetidine.114aLog D = AZ log D, calculated Log D at pH 7.4. bRat liver microsomes. cHuman liver microsomes. d% remaining after 30 minutes incubation. eNot determined.

Fig. 28