Fig. 38. Optimisation of a γ-secretase inhibitor.^170aHuman liver microsomes; Cl_int,app = total apparent intrinsic clearance from scaling in vitro t_1/2 in HLM. ^bThermodynamic solubility measured at pH 6.5. ^cApparent permeability coefficient in Ralph Russ canine kidney (RRCK) cells with low transporter activity.