Table 1.
Effect of NO releasing polymer plus top coat of immobilized argatroban on hemodynamics in a rabbit model of extracorporeal circuit.
| Uncoated (n=4) | DBHD (n=5) | AG/DBHD (n=5) | |
|---|---|---|---|
| Mean Blood Pressure (mmHg) | 37.8 ± 13.7 | 36.0 ± 2.1Ŧ | 36.3 ± 4.7Ŧ |
| Heart Rate (beats/min) | 140.0 ± 55.8 | 146.4 ± 43.7 | 133 ± 14.9 |
| Activated Clotting Time (sec) | 156.0 ± 72.5 | 227.2 ± 30.2Ŧ | 210.0 ± 34.9 |
| Fibrinogen | 174.3 ± 65.6 | 151.1 ± 49.5Ŧ | 163.8 ± 24.9Ŧ |
| White Blood Cell Count | 2586.8 ± 709.8Ŧ | 3683.8 ± 1609.7 | 3621.3 ± 565.3 |
| Flow Rate (mL/min) | 23.9 ± 25.1Ŧ* | 63.4 ± 13.4 | 83.0 ± 14.9 |
| Thrombin Clotting Time (sec) | 15.4 ± 1.6 | 15.0 ± 0.5Ŧ | 15.0 ± 0.4Ŧ |
Values are means ± SEM. Wilcoxon/Kruskal Wallis rank nonparametric test with multiple rank sum comparisons was done using SAS JMP 13 (Cary, NC).
*
p<0.05; between groups.
Ŧ
p<0.05; baseline vs 4 h.