TABLE 3.
Baseline Demographics, Characteristics, Comorbidities, and Inpatient Mortality of Coronavirus Disease 2019 Acute Respiratory Distress Syndrome Patients Requiring Mechanical Ventilation as Compared to Control
| Baseline Characteristics | Coronavirus Disease 2019 Acute Respiratory Distress Syndrome | Control | p | |
|---|---|---|---|---|
| n = 192 | n = 192 | |||
| Demographics | ||||
| Age, yr, mean (sd)a | Median (IQR) | 68 (57–76) | 68 (57–76) | |
| Black race | n (%) | 139 (73) | 61 (32) | < 0.001 |
| Malea | n (%) | 120 (63) | 120 (63) | |
| Comorbidities | ||||
| Asthma | n (%) | 21 (11) | 18 (9) | 0.736 |
| Chronic obstructive pulmonary disease | n (%) | 38 (20) | 52 (27) | 0.117 |
| Obstructive sleep apnea | n (%) | 34 (18) | 24 (13) | 0.199 |
| Diabetes | n (%) | 94 (49) | 67 (35) | 0.007 |
| Hypertension | n (%) | 151 (79) | 131 (68) | 0.028 |
| Coronary artery disease | n (%) | 41 (21) | 37 (19) | 0.704 |
| Congestive heart failure | n (%) | 37 (19) | 40 (21) | 0.799 |
| Chronic kidney disease | n (%) | 111 (58) | 55 (29) | < 0.001 |
| End-stage renal disease | n (%) | 9 (5) | 7 (4) | 0.799 |
| Tobacco use | n (%) | 72 (38) | 107 (56) | <0.001 |
| Prior deep vein thrombosis/pulmonary embolism | n (%) | 16 (8) | 38 (20) | 0.002 |
| Body mass index, kg/m2 | Median (IQR) | 31 (28–39) | 29 (25–34) | < 0.001 |
| Severity of illness | ||||
| Sequential organ failure assessment score | Median (IQR) | 11 (8–12) | 11 (8–14) | 0.121 |
| Lowest Pao2/Fio2b | Median (IQR) | 94 (80–145) | 95 (72–130) | 0.440 |
| Use of vasopressor | n (%) | 111 (58) | 69 (36) | < 0.001 |
| Use of paralytics | n (%) | 67 (35) | 47 (24) | 0.030 |
| Acute kidney injury | n (%) | 115 (60) | 114 (60) | 0.917 |
| Outcomes | ||||
| ICU-free days | Median (IQR) | 0 (0–0) | 2 (0–6) | < 0.001 |
| Ventilator-free days | Median (IQR) | 7 (0–17) | 7 (0–19) | 0.114 |
| Days on ventilator | Median (IQR) | 8 (4–13) | 11 (5–18) | < 0.001 |
| ICU length of stay | Median (IQR) | 13 (8–17) | 13.5 (9–23) | < 0.001 |
| Hospital length of stay | Median (IQR) | 13.5 (8–22) | 18 (11–30) | 0.087 |
| Inpatient mortality | n (%) | 122 (64) | 95 (49) | 0.007 |
IQR = interquartile range.
aVariables included in case-control selection.
bLowest Pao2/Fio2 ratio during the first 7 d of mechanical ventilation for acute respiratory distress syndrome.
Bolded p values indicate statistically significant values < 0.05.