TABLE 4.
Lung mechanics, Ventilation, and Fluid Status of Coronavirus Disease 2019 Acute Respiratory Distress Syndrome Patients Requiring Mechanical Ventilation as Compared to Control
| Variables | Coronavirus Disease 2019 Acute Respiratory Distress Syndrome | Control | p | ||
|---|---|---|---|---|---|
| n | Median (IQR) | n | Median (IQR) | ||
| Pao2/Fio2 | |||||
| Day 1 | 187 | 151 (105–225) | 191 | 105 (76–173) | 0.006 |
| Day 3 | 173 | 165 (109–209) | 151 | 164 (114–235) | 0.436 |
| Day 7 | 131 | 127 (88–180) | 102 | 185 (146–233) | < 0.001 |
| Static compliance | |||||
| Day 1 | 161 | 39 (30–54) | 152 | 35 (27–49) | 0.068 |
| Day 3 | 152 | 39 (30–54) | 137 | 33 (25–48) | 0.003 |
| Day 7 | 115 | 38 (28–48) | 107 | 36 (25–50) | 0.443 |
| Driving pressure | |||||
| Day 1 | 161 | 12 (9–15) | 152 | 14 (11–18) | < 0.001 |
| Day 3 | 152 | 12 (10–15) | 143 | 15 (11–18) | < 0.001 |
| Day 7 | 116 | 13 (10–15) | 108 | 14 (11–19) | 0.032 |
| Tidal volume measured; set (mL; cc/kg)a | |||||
| Day 1 | 185 | 455; 6 (391–539; 5–7) | 189 | 490; 7 (423–550; 6–8) | 0.087; 0.121 |
| Day 3 | 176 | 454; 5 (400–542; 4–6) | 171 | 466; 6 (400–564; 5–7) | 0.753; 0.319 |
| Day 7 | 133 | 450; 6 (393–524; 5–7) | 133 | 480; 5 (410–555; 4–6) | 0.289; 0.201 |
| Peak end-expiratory pressure (cm H2O) | |||||
| Day 1 | 185 | 12 (10–15) | 185 | 8 (5–12) | < 0.001 |
| Day 3 | 176 | 12 (10–15) | 167 | 10 (8–14) | 0.005 |
| Day 7 | 133 | 12 (8–16) | 129 | 8 (5–12) | < 0.001 |
| pH | |||||
| Day 1 | 189 | 7.36 (7.32–7.40) | 192 | 7.32 (7.23–7.38) | < 0.001 |
| Paco2 (mm Hg) | |||||
| Day 1 | 189 | 42 (38–47) | 192 | 43 (36–51) | 0.114 |
| Intake-output, net (mL) | |||||
| Day 1 | 188 | 528 (–205 to 1,882) | 188 | 2,050 (429–4,159) | < 0.001 |
| Day 3 | 181 | 1,059 (–298 to 2,733) | 172 | 1,917 (281–4,163) | < 0.001 |
IQR = interquartile range.
aSet tidal volumes as measured by ideal body weight in accordance with acute respiratory distress syndrome network.
Bolded p values indicate statistically significant values < 0.05.