Table 5.

ORs and 95% Cis for the MTHFR C677T and URPL under different models.

Contrast	Group	No.	I2(%)	Model ∗	Pooled OR(95% CI)	Egger (P value)	P value †
TT + CT vs CC	Overall	50	51.9	REM	1.91 (1.70–2.15)	.61
	HWE: yes	38	49.7	FEM	2.01 (1.84–2.19)	.75
	Distribution: North	25	59.6	REM	1.99 (1.65–2.39)		.57
	Distribution: South	25	43.0	FEM	1.86 (1.67–2.07)
TT vs CT + CC	Overall	50	57.0	REM	2.24 (1.93–2.60)	.03
	HWE: yes	38	58.5	REM	2.16 (1.83–2.56)	.11
	Distribution: North	25	69.1	REM	2.16 (1.74–2.68)		.47
	Distribution: South	25	31.2	FEM	2.24 (1.92–2.61)
CT vs CC	Overall	50	50.7	REM	1.59 (1.40–1.80)	.84
	HWE: yes	38	25.5	FEM	1.70 (1.55–1.87)	.44
	Distribution: North	25	53.9	REM	1.63 (1.36–1.96)		.98
	Distribution: South	25	49.4	FEM	1.60 (1.42–1.80)
TT vs CC	Overall	50	57.8	REM	3.06 (2.56–3.66)	.06
	HWE: yes	38	63.9	REM	2.95 (2.38–3.67)	.28
	Distribution: North	25	70.3	REM	3.10 (2.33–4.11)		.91
	Distribution: South	25	31.9	FEM	2.95 (2.48–3.49)
T vs C	Overall	50	61.3	REM	1.74 (1.60–1.90)	.70
	HWE: yes	38	69.2	REM	1.75 (1.57–1.95)	.99
	Distribution: North	25	69.8	REM	1.74 (1.53–1.97)		.92
	Distribution: South	25	49.3	FEM	1.73 (1.60–1.87)