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A schematic model of the role of SCRIB in regulating CRC. The upregulation of SCRIB reduced the expression of LATS1/2 and MOB1A/B to further inhibit the phosphorylation of YAP. Unphosphorylated YAP can translocate to the nucleus to activate transcription of the target genes TEAD1-4. The SCRIB-YAP-Hippo axis ultimately affects the disease progression of CRC patients by affecting the proliferation, invasion, migration, and apoptosis of CRC cells.
