Table 1. The demographic, clinical and laboratory characteristics of the studied groups.
| Demographic, Clinical and Laboratory Characteristics | Patients with active GD | Patients in normalized thyroid hormone levels | Controls | |
|---|---|---|---|---|
| (n = 35) | (n = 35) | (n = 40) | ||
| Demographic and Clinical Data | ||||
| Age at presentation; yrs | 9–18 (11.45 ± 1.50) | - | 8–18 (12.54 ± 1.62) | |
| P1-value | 0.323 | - | ||
| Gender | ||||
| Girls | 25 (71.43%) | 25 (71.43%) | 20 (50%) | |
| Boys | 10 (28.57%) | 10 (28.57%) | 20 (50%) | |
| Heart rate; beats/minute | 90–130 (110.00 ± 3.00) | 80–100 (90.00 ± 5.00) | 75–105 (85.00 ± 5.00) | |
| P1-value | 0.03 | 0.325 | ||
| P2-value | 0.01 | |||
| Systolic blood pressure; mmHg | 100–130 (110.00 ± 5.00) | 90–110 (100.00 ± 0.00) | 95–110 (100.00 ± 5.00) | |
| P1-value | 0.211 | 1.003 | ||
| P2-value | 0.212 | |||
| Diastolic blood pressure; mmHg | 60–80 (70.00 ± 0.00) | 60–75 (65.00 ± 5.00) | 55–80 (65.00 ± 0.00) | |
| P1-value | 0.456 | 1.002 | ||
| P2-value | 0.864 | |||
| Body Mass Index; kg/m2 | 16–25 (18.90 ± 4.30) | 18.5–26.9 (22.50 ± 2.30) | 18.5–28.9 (24.9 ± 2.30) | |
| P1-value | 0.135 | 0.426 | ||
| P2-value | ||||
| Laboratory Data | ||||
| TSH; μU/l | 0.005–0.22 (0.01 ± 0.006) | 0.37–3.55 (1.32 ± 0.45) | 0.62–4.42 (1.75 ± 0.86) | |
| P1-value | 0.0001 | 0.345 | ||
| P2-value | 0.0001 | |||
| fT4; pmol/l | 24.30–46.52(32.10 ± 2.68) | 7.25–16.33 (12.86 ± 1.36) | 7.54–14.96 (11.46 ± 1.45) | |
| P1-value | 0.520 | |||
| P2-value | 0.0001 | 0.0001 | ||
| fT3; pmol/l | 15.45–29.68 (19.45 ± 2.70) | 4.60–9.2 (5.50 ± 0.80) | 3.80–7.80 (5.26 ± 1.06) | |
| P1-value | 0.866 | |||
| P2-value | 0.0001 | 0.0001 | ||
| TRAb; IU/ml | 180.60–470.37 (265.74 ± 55.86) | 22.65–80.40 (42.36 ± 8.55) | 16.88–64.25 (46.45 ± 6.60) | |
| P1-value | 0.688 | |||
| P2-value | 0.0001 | 0.0001 | ||
| Intelligence Quotient (IQ) | ||||
| Verbal IQ | 80–130 (100.90 ± 10.28) | 80–140 (102.70 ± 15.60) | 90–145 (112.60 ± 18.55) | |
| P1-value | 0.345 | 0.433 | ||
| P2-value | 0.864 | |||
| Performance IQ | 70–135 (98.14 ± 12.33) | 70–145 (99.19 ± 13.58) | 86–132 (108.87 ± 15.60) | |
| P1-value | 0.235 | 0.268 | ||
| P2-value | 0.824 | |||
| Full scale IQ | 70–135 (101.18 ± 15.31) | 75–137 (100.06 ± 12.52) | 80–133 (105.90 ± 9.93) | |
| P1-value | 0.632 | 0.636 | ||
| P2-value | 1.022 | |||
Data are expressed as mean ± SD; number (%).
P1: significance versus controls; P2: significance versus those with active GD.
TSH: thyroid stimulating hormone; fT4: free thyroxine; fT3: free triiodothyronine; TRAbs, thyroid-stimulating hormone receptor antibodies.