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. 2021 Apr 15;12:637753. doi: 10.3389/fimmu.2021.637753

Figure 3.

Figure 3

LXA4 alleviates septic AKI. Male Sprague-Dawley rats were treated with or without LXA4 (100 µg/kg, i.p.) for 30-min or BOC-2 (50 mg/kg, i.p.) for 20min before CLP and were sacrificed at the time point of 18-h after surgery. Renal function alternation and renal necrosis were detected. (A–D) levels of SCr, BUN, urinary KIM-1 and NGAL among the four groups. (E) Renal damage of rats among the four groups (H&E; scale bar 100 μm). (F) Kidney histopathology evaluation scores among the four groups. Data are presented as mean ± SE (n = 8). **p < 0.01; ***p < 0.001; ****p < 0.0001; LXA4, Lipoxin A4; CLP, cecal ligation and puncture; H&E, hematoxylin–eosin staining; SCr, serum creatinine; BUN, blood urea nitrogen; KIM-1, kidney injury molecule-1; NGAL, neutrophil gelatinase-associated lipocalin.