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. 2021 Apr 15;12:637753. doi: 10.3389/fimmu.2021.637753

Figure 4.

Figure 4

LXA4 alleviates renal inflammation and tubular epithelial cell senescence. Levels of inflammatory cytokines and cellular senescence were detected. (A–C) levels of IL-6, TNF-α and HMGB1 at among the four groups. (D) Representative images of cellular senescence in kidneys after CLP (β-Gal staining; scale bar 100 μm); Red: β-Gal positive threshold. (E) quantitative analysis of senescent tubular area among the four groups. (F–H) expression of p53 and p21 protein in kidney tissues among the four groups. (I) Representative images of cellular senescence in NRK52E cells after LPS treatment (β-Gal staining). (J) Expression of p53 and p21 protein in NRK52E cells after LPS treatment. Data are presented as mean ± SE (n = 8). ***p < 0.001; ****p < 0.0001; CLP, cecal ligation and puncture; IL-6, interlecukin-6; IL-8, interlecukin-8; TNF-α, tumor necrosis factor-alpha; LPS, lipopolysaccharide.