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. 2021 Apr 15;12:637753. doi: 10.3389/fimmu.2021.637753

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Copyright © 2021 Chen, Qiu, Yang, Zhang, Sun, Gao, Hei and Ji

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LXA4 attenuates septic AKI via inhibition of PPAR-γ/NF-κB pathway. Expression of p-p65, p53 and p21 in the neighbored section and levels of inflammatory cytokines in NRK52E cells and kidneys were also detected. (A) Expression of p-p65 and p53 in the NRK52E cells were detected by IF. (B) Expression of p-p65, p53 and p21 in the neighbored kidney sections were detected by IF. (C–E) levels of IL-6, TNF-α and HMGB1 at among the four groups. Data are presented as mean ± SE (n = 8). *p < 0.05; **p < 0.005; ***p < 0.001; ****p < 0.0001; LXA4, Lipoxin A4; RSG, Rosiglitazone; CLP, cecal ligation and puncture; IL-6, interlecukin-6; IL-8, interlecukin-8; TNF-α, tumor necrosis factor-alpha.