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. 2021 Apr 28;41(17):3764–3776. doi: 10.1523/JNEUROSCI.2843-20.2021

Figure 7.

Figure 7.

CaV2.1/2.2 contribute to AIS calcium in the somatosensory cortex. A, Representative effect of ω-conotoxin MVIIC application on AIS calcium in layer 5b pyramidal cells in the somatosensory cortex. Left, Example time-locked control cell. Black, baseline; gray, post. Right, Example of the effect of ω-conotoxin MVIIC. Black, baseline; green, ω-conotoxin MVIIC. Linescan data are plotted as mean ± SE. B, Summary of the effects of ω-conotoxin MVIIC on AIS calcium in somatosensory layer 5b pyramidal neurons. Black, time-locked control cells; green, ω-conotoxin MVIIC. *p < 0.05, Mann-Whitney U test. C, Decreases in EPSP amplitude confirm the presence of ω-conotoxin MVIIC at the slice. Top, Representative examples of EPSPs in ω-conotoxin MVIIC (right) or in time-locked control cells (left). Bottom, Summary of the effects of ω-conotoxin MVIIC on EPSP amplitude in somatosensory cortex. Black, baseline; gray, time-locked control; green, ω-conotoxin MVIIC. *p < 0.05, Mann-Whitney U test.