Figure 6.

Increased activation to novel and repeated stimuli is associated with entorhinal tau pathology in OAs. Mean FTP SUVR of native space entorhinal cortex (EC) was extracted and partial volume corrected for each OA subject. To obtain measures of activity, the mean β value for each ROI was extracted for novel and repeated stimuli (compared to perceptual baseline). Robust regressions were performed to reduce the effects of outliers. All correlations controlled for age, sex, and EC thickness (raw data shown). EC FTP SUVR was associated with increased activity to both novel and repeated stimuli in A35 (A), pmEC (B), and hippocampus (D), but not alEC (C); * indicates significant skipped correlations (CI does not include zero). Black data points were identified as bivariate outliers and removed in the skipped correlation.