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. 2021 Apr 19;17(4):e1009522. doi: 10.1371/journal.ppat.1009522

Fig 6. Induction of tissue retention signature in effector memory CD4 T cells by pDCs.

Fig 6

The geometric mean FI of residency-associated proteins (CD127, CXCR6, PD1) and non-resident markers (CXCR3 and CD62L) in (A) total HIV infected CD4 TEM cocultured with pDCs and (B) in CD69+ versus CD69– expressing CD4 TEM co-cultured with pDCs (n = 4–6 respectively). (C) Representative gating strategy identifying CD69+ tissue resident CD4 T cells isolated via enzymatic digestion of a human rectum. (D) The geometric mean FI of residency-associated proteins (CD127, CXCR6, PD1) and non-resident markers (CCR7, CXCR3) in CD69+ and CD69– expressing CD4 T cells isolated from human rectal epithelium (n = 1), rectal lamina propria (n = 3) and outer foreskin mixed epidermis and dermis (n = 3) tissues. For all data, *p < 0.05, **p < 0.01 by paired two-sided t-test.