Skip to main content
. 2020 Dec 3;47(3):803–811. doi: 10.1093/schbul/sbaa164

Fig. 2.

Fig. 2.

Comparison of epigenetic age acceleration and chronological age between unaffected controls and schizophrenia patients. Epigenetic age accelerationDiff (A, D) and accelerationResidual (B, E) or chronological age (C, F) from unaffected control (blue) or schizophrenia (red) are shown with columns with standard error indicated by bars from whole blood (A–C) or brain frontal cortex (D–F). Significant differences in epigenetic age accelerationDiff and accelerationResidual or chronological age between unaffected control and schizophrenia by Kruskal-Wallis tests were shown with P < .05 above each panel. The epigenetic age acceleration was determined by calculating AccelerationDiff (ie, DNAm age minus chronological age) and AccelerationResidual (the residual resulting from linear regressing DNAm age on the chronological age), and a positive (negative) value of AccelerationDiff or AccelerationResidual indicates that the DNAm age of a given tissue is higher (or lower) than chronological age.