Table 3.

Associations Between CRP and Offspring Clinical and Academic Outcomes at Ages 7 and 16 Years

		Unadjusted Analysis		Adjusted Analysisc
Outcome	Samplea	Odds Ratio/Beta (95% CI)b	P-value	Odds Ratio/Beta (95% CI)b	P-value
Possible psychotic experiences	4089	1.163 (1.03, 1.31)	.014	1.093 (0.96–1.24)	.176
Ever smoked age 16	4596	0.952 (0.90, 1.01)	.097	0.941 (0.88–1.00)	.058
Ever cannabis age 16	4267	1.223 (1.07, 1.40)	.003	1.240 (1.07–1.43)	.003
Standard age 7	5279	1.080 (0.99, 1.18)	.096	1.016 (0.92–1.12)	.758
Better academic performance age 16	5621	0.072 (−0.099, −0.046)	<.001	−0.062 (−0.088, −0.036)	<.001

Note: CRP, C-reactive protein.

^a N includes all those with data available on all covariates (sex, maternal education level, maternal BMI during pregnancy, smoking during pregnancy, alcohol use during pregnancy, place of birth, maternal psychiatric admission, paternal psychiatric admission, mothers age at birth, and gestational week of CRP sample).

^bOdds ratio for the increased risk associated with 1 standard deviation increase.

^cAfter controlling for sex, maternal education level, maternal BMI during pregnancy, smoking during pregnancy, alcohol use during pregnancy, place of birth, maternal psychiatric admission, paternal psychiatric admission, mothers age at birth, and gestational week of CRP sample.