Table 1. Characteristics of patients identified in multicenter surveillance for Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae, Italy*.
| Characteristics | KPC-Kp patients, n = 1,071 |
|---|---|
| Sex | |
| M | 694 (64.8) |
| F |
377 (35.2) |
| Median age (IQR) |
72 (61–80) |
| Ward of isolation | |
| Intensive care unit | 275 (25.7) |
| Infectious diseases | 81 (7.6) |
| Surgery | 149 (13.9) |
| Geriatrics | 47 (4.4) |
| Oncology | 34 (3.2) |
| Hematology | 42 (3.9) |
| Other medical wards |
443 (41.4) |
| KPC-Kp colonization in previous 12 mo | 333 (31.1) |
| Hospitalization in previous 12 mo | 865 (80.8) |
| Antimicrobial therapy in the 30 d before hospitalization | 782 (73.0) |
| Major surgery in the previous 30 d |
262 (24.4) |
| Underlying conditions† | 989 (92.3) |
| Congestive heart failure | 192 (17.9) |
| Peripheral vascular disease | 197 (18.4) |
| Cerebrovascular disease | 205 (19.1) |
| Chronic lung disease | 202 (18.9) |
| Chronic renal failure | 304 (28.4) |
| Cancer | 244 (22.8) |
| Diabetes |
163 (15.2) |
| Charlson index, median (IQR) | 6 (4–8) |
| Central venous catheter at isolation | 414 (38.7) |
| Urinary catheter at isolation | 562 (52.5) |
| Immunosuppressive therapy | 209 (19.5) |
| Days of hospitalization, median (IQR) |
25 (14–45) |
| KPC-Kp acquisition characteristics‡ | |
| Severe infection | 221 (20.6) |
| Mild infection | 109 (10.2) |
| Colonizationsur |
741 (69.2) |
| Median time from hospitalization to isolation of strain, d (IQR)‡ | |
| Severe infection | 12 (2–22) |
| Mild infection | 11 (2–25) |
| Colonizationsur |
6 (1–17) |
| Median time from strain isolation to discharge or death, d (IQR)‡ | |
| Severe infection | 18 (9–35) |
| Mild infection | 20 (12–35) |
| Colonizationsur | 13 (6–22) |
*Values are no. (%) except as indicated. IQR, interquartile range; KPC-Kp, Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae. †Underlying conditions and devices are listed when present in >10% of patients. ‡Severe infection included bloodstream or lower respiratory tract infection plus septic shock from other sites; Mild infection included infections from other sites; and colonizedsur patients were identified through surveillance protocols.