FIG. 8.

Integrating the Insert-Chip with MEA devices. (a) Photograph showing the Insert-Chip integrated in the MEA platform allowing for simultaneous TEER and electrophysiological measurements. (b) Rat hippocampal neurons cultured on the MEA device for 10–12 days in vitro. (c) TEER plot of HUVEC cultured on the Insert-Chip and integrated with the MEA. (d) Extracellular electrophysiological recordings of neuronal spontaneous activity recorded from 14 different electrodes after 10 days in vitro, simultaneously integrated with HUVEC grown on the Insert-Chip. Each color represents a different electrode.