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. 2021 Apr 30;88:1–8. doi: 10.1016/j.ejim.2021.04.019

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© 2021 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 1 — Schematic mechanism of action of mRNA and adenoviral vector DNA vaccines and their potential cardiovascular interactions throughout the activation of the immune system and the interaction between free-floating Spike proteins and ACE2 (see text for details).

Legend: AII=angiotensin 2; A_1,7=angiotensin1,7; ACE2=angiotensin converting ezyme 2 receptor; DNA= deoxyribonucleic acid; RNA= ribonucleic acid; mRNA=messenger ribonucleic acid.