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. 2021 Apr 30;88:1–8. doi: 10.1016/j.ejim.2021.04.019

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© 2021 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

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Fig. 3 — Use of vaccines with DNA templates or mRNA encoding mutated Spike proteins with conformational change as alternative therapeutic strategy to ameliorate the potential detrimental effects of the interactions between ACE2 and Spike proteins (see text for details).

Legend: AII=angiotensin 2; A_1,7=angiotensin1,7; ACE2=angiotensin converting ezyme 2 receptor.