Table 2.
Spearman's correlation of serum PGRN and EphA2 levels with risk factors and the Gensini score.
| Variable | PGRN (ng/mL) | EphA2 (pg/mL) | ||
|---|---|---|---|---|
| r | p value | r | p value | |
| Males, n (%) | -0.003 | 0.964 | 0.103 | 0.148 |
| Age (y) (mean ± SD) | -0.018 | 0.800 | 0.221 | 0.002 |
| BMI (kg/m2) | 0.013 | 0.864 | -0.147 | 0.054 |
| Hypertension, n (%) | 0.016 | 0.818 | -0.021 | 0.772 |
| Diabetes mellitus, n (%) | 0.024 | 0.737 | 0.064 | 0.368 |
| Smoking, n (%) | -0.051 | 0.474 | -0.024 | 0.740 |
| eGFR (mL/min/1.73 m2) | -0.075 | 0.303 | -0.161 | 0.027 |
| Total cholesterol (mg/dL) | 0.078 | 0.278 | 0.186 | 0.008 |
| LDL (mg/dL) | 0.041 | 0.563 | 0.231 | 0.001 |
| Hemoglobin A1c (%) | 0.120 | 0.120 | 0.035 | 0.647 |
| NT-proBNP (pg/mL) | 0.185 | 0.009 | 0.389 | <0.001 |
| cTnT (ng/mL) | 0.199 | 0.005 | 0.451 | <0.001 |
| CK-MB (U/L) | 0.111 | 0.123 | 0.225 | 0.001 |
| hs-CRP (mg/L) | 0.182 | 0.010 | 0.278 | <0.001 |
| PGRN (ng/mL) | / | / | 0.407 | <0.001 |
| EphA2 (pg/mL) | 0.407 | <0.001 | / | / |
| Gensini score | 0.099 | 0.170 | 0.306 | <0.001 |
| LVEF (%) | -0.215 | 0.003 | -0.405 | <0.001 |
| CTO | 0.147 | 0.041 | 0.330 | <0.001 |
BMI: body mass index; eGFR: estimated glomerular filtration rate; LDL: low-density lipoprotein; NT-proBNP: N-terminal pro B-type natriuretic peptide; cTnT: cardiac troponin T; CK-MB: creatine kinase-MB; hs-CRP: hypersensitive C-reactive protein; PGRN: progranulin; EphA2: Eph-receptor tyrosine kinase-type A2; LVEF: left ventricular ejection fraction; CTO: chronic total occlusion.