Table 7.
Effect of MCEO on gastric juice parameters in pylorus-ligation model in rats.
| Groups | Gastric juice parameter | ||||
|---|---|---|---|---|---|
| Ulcer area (mm2) | Protection (%) | Volume (ml) | pH (unit) | Total acidity (m equiv./L) | |
| Disease control (distilled water) | 12.3 ± 1.7 | — | 3.2 ± 0.4 | 2.2 ± 0.4 | 2927.0 ± 442.1 |
| Ranitidine (100 mg/kg) | 6.7 ± 0.6∗ | 46.0 | 2.2 ± 0.2 | 4.2 ± 0.2∗∗∗ | 2773.0 ± 452.7 |
| MCEO (10 mg/kg) | 8.3 ± 1.1 | 32.4 | 2.3 ± 0.4 | 2.9 ± 0.3 | 3020.0 ± 663.8 |
| MCEO (50 mg/kg) | 10.7 ± 1.5 | 13.5 | 4.1 ± 1.0 | 4.0 ± 0.2∗∗∗ | 5700.0 ± 59.1∗∗ |
| MCEO (100 mg/kg) | 7.0 ± 0.7∗ | 43.2 | 3.0 ± 0.8 | 4.0 ± 0.2∗∗∗ | 3380.0 ± 734.0 |
Data are expressed as mean ± SEM, n = 6, ∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.005. Dunnett's test as compared to disease control value.