Skip to main content
. 2021 Apr 21;2021:6654220. doi: 10.1155/2021/6654220

Figure 3.

Figure 3

Differential expression of CCR2 and CCR4 in peripheral blood monocytes from MDR-TB and DS-TB patients. Representative zebra plots showing the strategy of analysis used to evaluate CCR2 and CCR4 expression in total CD14+ monocytes by flow cytometry. Peripheral blood mononuclear cells (PBMCs) from multidrug-resistant (MDR-TB) or drug-sensitive (DS-TB) patients were obtained at different time points before and after anti-TB treatment and employed for phenotypical characterization (a and c, respectively). (b) Frequency of CD14+CCR2+, CD14+CCR2+CCR4+, and CD14+CCR4+ subpopulations in MDR-TB patients (HD: n = 6, MDR-TB: basal, 1, and 3 moTBt n = 10, 8 moTBt n = 8, and 16 moTBt n = 7). (d) Frequency of CD14+CCR2+, CD14+CCR2+CCR4+, and CD14+CCR4+ subpopulations in DS-TB patients (HD n = 6; DS-TB: basal, and 1 moTBt n = 10, and 6 moTBt n = 8). Bar graphs display means ± standard error of the mean (SEM). Differences between patient groups and HD at each time point were analyzed using multiple Student's t-test corrected for multiple comparisons using the Sidak–Bonferroni method. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, and ∗∗∗∗p < 0.0001. moTBt: months of antituberculosis treatment.