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. 2021 Apr 21;2021:6654220. doi: 10.1155/2021/6654220

Figure 7.

Figure 7

Expression of CXCR1 and CXCR3 in CD8+T cells from MDR-TB and DS-TB patients. Representative zebra plots showing the strategy used to determine the expression of CXCR1 and CXCR3 CD3+CD8+ T cells. Peripheral blood mononuclear cells (PBMCs) from multidrug-resistant (MDR-TB) or drug-sensitive (DS-TB) patients were obtained at different times before and after anti-TB treatment and used for phenotypical characterization by flow cytometry (a and c, respectively). (b) Frequency of CD8+CXCR1+, CD8+CXCR1+CXCR3+, and CD8+CXCR3+ T cell subpopulations in MDR-TB patients (HD: n = 6, MDR-TB: basal, 1, and 3 moTBt n = 10, 8 moTBt n = 8, and 16 moTBt n = 7). (d) Frequency CD8+CXCR1+, CD8+CXCR1+CXCR3+, and CD8+CXCR3+ T cell subpopulations in DS-TB patients (HD: n = 6, DS-TB: basal and 1 moTBt n = 10, and 6 moTBt n = 8). Bar graphs show means ± standard error of the mean (SEM). Differences between patient groups and HD at each time point were analyzed using multiple Student's t-test corrected for multiple comparisons using the Sidak–Bonferroni method. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, and ∗∗∗∗p < 0.0001. moTBt: months of antituberculosis treatment.