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. Author manuscript; available in PMC: 2021 Apr 29.
Published in final edited form as: J Am Acad Child Adolesc Psychiatry. 2020 Jan 23;60(2):252–261.e3. doi: 10.1016/j.jaac.2019.12.007

FIGURE 3.

FIGURE 3

Effects of Continuous Pediatric Prolonged-Release Melatonin (PedPRM) Treatment on Pubertal Development

Note: Effects of continuous PedPRM treatment (104 weeks PedPRM, 91 weeks placebo) on (A) male and female participant pubic hair growth by age (n = 31), (B) female participant breast development by age (n = 7), and (C) male participant genitalia development by age (n = 24). The individual standard deviation scores (SDS) at baseline (week 2, blue) and end of PedPRM treatment (week 106, red) are depicted. Normal ranges are marked on the right-hand y-axis.39