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. 2021 Apr 1;40(17):3087–3100. doi: 10.1038/s41388-021-01754-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Heat map of top 36 significantly up-regulated and top 20 significantly down-regulated genes of stromal PF179TCAF-shGR-1 cells. B Significantly altered GR target genes of PF179TCAF-shGR-1 cells, after control DMSO treatment as well as after 100 nM Dex, 100 nM Dex + 1 µg/ml Dox, and 100 nM Dex and 12 µM RU486 treatment for 24 h. C Heat map of top 36 significantly up-regulated and top 20 significantly down-regulated genes of epithelial abl-Enza and abl-Abi cells. D Significantly altered GR target genes of abl-Enza and abl-Abi cells, after control DMSO treatment as well as after 100 nM Dex treatment for 24 h. E Identification of 27 mutual significantly up-regulated GR target genes between the LREX´ and abl-Enza/Abi datasets. F Identification of four mutual significantly up-regulated stromal and epithelial GR target genes within the CAF, abl-Enza/Abi and LREX´ datasets.