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. 2021 Apr 6;40(17):3164–3179. doi: 10.1038/s41388-021-01762-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Scatter plot of expression of various lncRNAs in the exosomes of pancreatic cancer cells and normal pancreatic ductal epithelial cells. The lncRNAs above the top red line and below the bottom blue line are those upregulated or downregulated more than twofold. T: pancreatic cancer cell exosomes; N: normal pancreatic ductal epithelial cell exosomes. B Volcano plot depicting the differential expression between these two groups. The red and blue dots represent lncRNAs with more or less than twofold changes in expression, respectively. C Hierarchical cluster analysis of the top 20 upregulated lncRNAs in pancreatic cancer cell exosomes matched with normal pancreatic ductal epithelial cell exosomes. D Histogram depicting the relative expression of the top 20 upregulated lncRNAs in pancreatic cancer cell exosomes compared with normal pancreatic ductal epithelial cell exosomes. E–H We detected the expression of top four upregulated lncRNAs in samples from 32 pairs pancreatic cancer tissues by qRT-PCR. All experiments were repeated three times, and the significance was analyzed using a Student’s t test. Data are shown as mean ± SD (**P < 0.01 and ***P < 0.001 vs. control).