Table 2.
Association between LAG-3 expression and other tumor-infiltrating lymphocyte subsets in (A) the overall cohort and (B) the IDH-wt glioblastoma cohort
| (A) | Overall cohort | LAG-3 | ||
|---|---|---|---|---|
| n = 97 | + | − | ||
| CD3 | + | 10 | 55 | p = 0.029 |
| − | 0 | 32 | ||
| CD8 | + | 9 | 30 | p = 0.001 |
| − | 1 | 57 | ||
| PD-1 | + | 7 | 7 | p < 0.001 |
| − | 3 | 80 | ||
| PD-L1 | + | 8 | 35 | p = 0.021 |
| − | 2 | 52 | ||
| Median (range) | 1% (0–70%) | 0% (0–60%) | p = 0.052 | |
| (B) | IDH-wt glioblastoma | LAG-3 | ||
|---|---|---|---|---|
| n = 68 | + | − | ||
| CD3 | + | 10 | 38 | p = 0.020 |
| − | 0 | 20 | ||
| CD8 | + | 9 | 19 | p < 0.001 |
| − | 1 | 39 | ||
| CD20 | + | 6 | 12 | p = 0.017 |
| − | 4 | 46 | ||
| PD-1 | + | 7 | 7 | p < 0.001 |
| − | 3 | 51 | ||
| PD-L1 | + | 8 | 32 | p = 0.179 |
| − | 2 | 26 | ||
| Median (range) | 1% (0–70%) | 1% (0–60%) | p = 0.436 | |
P-values as determined by Fisher’s exact test
Bold p-values indicate p ≤ 0.05