Table 1.
Dysregulation of exosomal circRNAs in cancer biology
| circRNA | Cancer type | Expression | Biological function | Mechanism | Citation |
|---|---|---|---|---|---|
| circ-0051443 | HCC | Downregulated | Promote cell apoptosis and arrest the cell cycle | circ-0051443/miR-331-3p/BAK1 | [80] |
| circ-DB | HCC | Upregulated | Promote growth and reduce DNA damage | circ-DB/miR-34a /USP7 | [81] |
| Cdr1as | HCC | Upregulated | Promote proliferation and migration | Cdr1as/miR-1270/AFP | [82] |
| circNRIP1 | GC | Upregulated | Promote tumour metastasis | circNRIP1/miR-149-5p/AKT1 | [83] |
| ciRS-133 | GC | Upregulated | Promote cancer-associated cachexia | ciRS-133/miR-133/PRDM16 | [5] |
| Circ-RanGAP1 | GC | Upregulated | Promote invasion and metastasis | circ-RanGAP1/miR-877-3p/VEGFA | [24] |
| circLONP2 | CRC | Upregulated | Promote invasion and metastasis | circLONP2 /miR-17/DGCR8 | [84] |
| ciRS-122 | CRC | Upregulated | Promote glycolysis and drug resistance | ciRS-122/miR-122/PKM2 | [85] |
| circ-ABCC1 | CRC | Upregulated | Promote cell stemness, sphere formation and metastasis | circ-ABCC1/Wnt /β-catenin | [86] |
| circIFT80 | CRC | Upregulated | Promote the proliferation, migration and invasion | circIFT80 /miR-1236-3p /HOXB7 | [87] |
| circFMN2 | CRC | Upregulated | Promote proliferation and migration | circFMN2/miR-1182 /hTERT | [88] |
| circ-PDE8A | PDAC | Upregulated | Promote proliferation and invasion | Circ-PDE8A /miR-338/MACC1 | [25] |
| Circ-IARS | PDAC | Upregulated | Promoting tumor invasion and metastasis | circ-IARS/miR-122/RhoA | [89] |
| CircPUM1 | ovarian cancer | Upregulated | Promote proliferation, migration and invasion | CircPUM1 /miR-615-5p/miR-6753-5p/NF-Κb/MMP2 | [90] |
| CircWHSC1 | ovarian cancer | Upregulated | Promote proliferation and metastasis | CircWHSC1/miR-145/miR-1182 | [91] |
| Cdr1as | ovarian cancer | Downregulated | Inhibit proliferation and promot cisplatin-induced cell apoptosis | Cdr1as/miR-1270/SCAI | [92] |
| CircSATB2 | NSCLC | Upregulated | Promotes proliferation, migration and invasion | circSATB2/miR-326/FSCN1 | [93] |
| Circ_0044516 | prostate cancer | Upregulated | Promote growth and metastasis | Circ_0044516/miR‐29a‐3p | [94] |
| CircPRMT5 | UCB | Upregulated | Promote growth and metastasis | circPRMT5/miR-30c/SNAIL1/E-cadherin | [95] |
| circRASSF2 | LSCC | Upregulated | Promote proliferation | circRASSF2/miR-302b-3p/IGF-1R | [96] |
| mc-COX2 | CLL | Upregulated | Promote proliferation and inhibit apoptosis | – | [97] |
| CircRASSF2 | PTC | Upregulated | Promote proliferation and inhibit apoptosis | CircRASSF2/miR-1178/TLR4 | [98] |
HCC hepatocellular carcinoma, GC gastric cancer, CRC colorectal cancer, PDAC pancreatic ductal adenocarcinoma, NSCLC non-small cell lung cancer, UCB urothelial carcinoma of the bladder, PTC papillary thyroid carcinoma, LSCC laryngeal squamous cell carcinoma, CLL chronic lymphocytic leukemia