Table 2.
Dysregulation of exosomal circRNAs in other diseases
| circRNA | Diseases | Expression | Biological function | Mechanism | Citation |
|---|---|---|---|---|---|
| CircHIPK3 | Cardiomyocytes | Upregulated | Decrease in oxidative stress-induced CMVECs dysfunction | CircHIPK3/miR-29a/IGF-1 | [107] |
| cZFP609 | Ischemic diseases | Upregulated | Inhibit endothelial angiogenic activity induced by hypoxia | cZFP609 /HIF1α/VEGFA | [108] |
| circHIPK3 | Ischemic injury of the skeletal muscle | Downregulated | Improve blood perfusion, inhibit ischemia induced pyroptosis | circHIPK3/miR-421 /FOXO3a | [32] |
| circ-Rtn4 | Osteoporosis | Upregulated | Increase cell activity and inhibit apoptosis | circ-Rtn4/miR-146a/TNF-α | [109] |
| circRNA-0077930 | Vascular smooth muscle aging | Upregulated | Promote cellular senescence of VSMCs | circRNA-0077930/miR-622/Kras | [110] |
CMVECs cardiac microvascular endothelial cells